• Getting to the Heart o...
    In this issue of Healthy Living, the focus is on Eisenhower’s Cardiovascular Center of Excellence — a fitting topic to start the New Year as many of us make resolutions to improve our fitness. The... click for more
  • 11th Annual Community ...
    February is Heart Month and a great time to educate oneself about heart health. For Coachella Valley residents, the Community Heart and Stroke Conference — presented by Eisenhower Smilow Heart Center and Eisenhower Desert Cardiology Center — is the perfect opportunity to do just that!

    The 11th Annual Community Heart Conference will be held Saturday, February 1 from 8 a.m. to 1:30 p.m. at the Annenberg Center for Health Sciences at Eisenhower. The popular annual event focuses on the prevention and symptoms of heart disease and stroke as well as the latest treatments for those living with cardiovascular issues. Attendees should be 18 years of age or older. Reservations are not required. click for more

  • Eisenhower Medical Cen...
    Eisenhower Medical Center has again received full accreditation as a chest pain center from the Society of Cardiovascular Patient Care (SCPC). Originally accredited in 2006 and then in 2009,... click for more
  • How to Live a Long, Sw...
    Zorba Paster, MD, Professor of Fam ily Medicine at the University of Wisconsin School of Medicine and host of the popular National Public Radio show On Your Health, will be the guest speaker at the... click for more
  • Celebrity Golf Invitat...
    The 26th annual Frank Sinatra Celebrity Invitational, benefiting the Barbara Sinatra Children’s Center for Abused Children, tees off February 20-22, 2014. Eagle Falls Golf Course and Fantasy Springs... click for more
  • 5 Things
    (1) Breathe, Long and Deep
    Practice long, deep breaths — at home, in your car, at work or anytime. The increased oxygen and slower pace will benefit your body and your mind.

    (2) Find a New Recipe
    Surprise your family and your taste buds — find a new healthy recipe to make for dinner

    (3) Visit Your Local Library
    Plan to spend a couple of hours exploring your favorite book aisles or consider choosing a topic you’ve never read!   click for more
  • Cheeky’s No Ordinary M...
    It may sound cheeky , but the worst thing about this Palm Springs eatery is the menu. After all, when everything sounds this enticing, how can you possibly decide what to order?

    Will you have the rainbow chard frittata with fried eggplant wheels? Or maybe you’re more interested in the pumpkin bread pudding French toast. How about the braised short rib hash with crispy skillet Yukon golds and sunny eggs?

    And that’s just breakfast. Flip the menu over, and you’ll see dozens of lunch options, each one more mouthwatering than the last. No wonder Vogue magazine visited Cheeky’s and declared, “Its menu means business.” click for more

  • Watercolor Painting
    Imagine a quiet place — a sturdy table, a comfortable chair, a tablet of thick paper, brushes and a palette of bright colors. You have cleared your schedule, turned your electronic devices off and all that remains is creative possibility and the rhythm of steady breathing. You are ready to begin.

    Painting is one of the best ways to be present — to be in the moment. Think of it as something as important as exercise. Carve out a few hours each week, during your morning, your evening or on the weekend. You might even schedule a weekly date with your brushes and paper. click for more

  • Sunnylands
    For decades, desert dwellers have wondered what lies beyond the pink walls of Sunnylands, the private estate of Walter and Leonore Annenberg. The sprawling, 200-acre Rancho Mirage property has been... click for more

Advanced Prostate Cancer

The Latest Treatments

Murthy Andavolu, MD
Murthy Andavolu, MD
When prostate cancer is in its early stages, immediate treatment may not be necessary. Depending on a patient’s age and other determining factors, watchful waiting is an option — followed by radiation and surgery as the next line of defense. However, if the cancer has metastasized, spreading to other parts of the body, physicians have access to an array of systemic treatments.

According to Eisenhower Medical Center physician Murthy Andavolu, MD, MBA, Board Certified in Internal Medicine, Medical Oncology and Hematology, prostate cancer is the medical parallel to breast cancer in women. “Pathologically and physiologically, prostate cancer is the equivalent of female breast cancer — a hormonally dependent, hormonally driven cancer,” says Dr. Andavolu. “And, advanced prostate cancer is responsive to hormone treatments. As a result, hormone treatments are becoming more and more center stage in the treatment of prostate cancer as opposed to chemotherapy, although it is not the only mode of treatment.”

Hormone Therapies
Two of the most recent hormone therapies garnering good results are Zytiga® and Xtandi®. Zytiga, a prescription medicine used in combination with prednisone (a synthetic corticosteroid drug), works by interrupting the androgen-making process (androgen is a male hormone such as testosterone). Xtandi is a oncea- day prescription medicine that lessens the ability of androgens to attach to and activate the androgen receptor which may decrease prostate cancer cell growth. “A trial with Xtandi in patients who have not yet received chemotherapy has shown a significant prolongation in survival for patients who are receiving the hormone therapy even before chemotherapy,” notes Dr. Andavolu.

Immunotherapy
If hormonal treatments do not prove effective in a patient, physicians look to immunotherapy.

“There are currently two different immunotherapies available, one of which is approved and one which is undergoing clinical trails and could be approved,” explains Dr. Andavolu.

Provenge® is an approved immunotherapy for advanced prostate cancer patients. “This is a very personalized treatment where we take the patient’s blood cells and deliver an antibody against an antigen [any substance that causes the immune system to produce antibodies against it] that is expressed by the prostate cancer cells. The antibody goes to the prostate cancer and the antigen on the prostate cancer cells. This is a targeted, individualized therapy for a patient’s prostate cancer antigen,” says Dr. Andavolu.

Chemotherapy
If patients fail to respond to hormone therapies and immunotherapy, physicians turn to chemotherapy to treat advanced prostate cancer patients. The chemotherapy drug Taxotere® works by preventing cancer cells from dividing and growing. A newer chemotherapy, Jevtana®, may fight tumors that have become resistant to Taxotere. In patients suffering from bone pain due to advanced cancer metastases, radiation treatment can help to ease pain. A radiopharmaceutical bone-seeking isotope delivered intravenously can also help with painful bone metastasis.

On the Horizon
Although the treatment of advanced prostate cancer from a surgical standpoint has remained relatively static, the availability of hormone therapy treatment during the past two years has significantly prolonged the survival of patients. “Hormone therapies should be used first, followed by immunotherapy, and then chemotherapy,” says Dr. Andavolu. “It’s the best approach for the management of advanced prostate cancer.”